BackgroundThe Transparency and Openness Promotion Guidelines describe modular standards that journals can adopt to promote open science. The TOP Factor is a metric to describe the extent to which journals have adopted the TOP Guidelines in their policies. Systematic methods and rating instruments are needed to calculate the TOP Factor. Moreover, implementation of these open science policies depends on journal procedures and practices, for which TOP provides no standards or rating instruments.MethodsWe describe a process for assessing journal policies, procedures, and (...) practices according to the TOP Guidelines. We developed this process as part of the Transparency of Research Underpinning Social Intervention Tiers Initiative to advance open science in the social intervention research ecosystem. We also provide new instruments for rating journal instructions to authors, manuscript submission systems, and published articles according to standards in the TOP Guidelines. In addition, we describe how to determine the TOP Factor score for a journal, calculate reliability of journal ratings, and assess coherence among a journal’s policies, procedures, and practices. As a demonstration of this process, we describe a protocol for studying approximately 345 influential journals that have published research used to inform evidence-based policy.DiscussionThe TRUST Process includes systematic methods and rating instruments for assessing and facilitating implementation of the TOP Guidelines by journals across disciplines. Our study of journals publishing influential social intervention research will provide a comprehensive account of whether these journals have policies, procedures, and practices that are consistent with standards for open science and thereby facilitate the publication of trustworthy findings to inform evidence-based policy. Through this demonstration, we expect to identify ways to refine the TOP Guidelines and the TOP Factor. Refinements could include: improving templates for adoption in journal instructions to authors, manuscript submission systems, and published articles; revising explanatory guidance intended to enhance the use, understanding, and dissemination of the TOP Guidelines; and clarifying the distinctions among different levels of implementation.Research materials are available on the Open Science Framework: https://osf.io/txyr3/. (shrink)

Here we challenge the orthodoxy according to which abduction is an a posteriori mode of inference. We start by providing a case study illustrating how abduction can justify a philosophical claim not justifiable by empirical evidence alone. While many grant abduction's epistemic value, nearly all assume that abductive justification is a posteriori, on grounds that our belief in abduction's epistemic value depends on empirical evidence about how the world contingently is. Contra this assumption, we argue, first, that our belief (...) in abduction’s epistemic value is not and could not be justified a posteriori, and second, that attention to the roles experience plays in abductive justification supports taking abduction to be an a priori mode of inference. We close by highlighting how our strategy for establishing the a priority of abduction positively contrasts with strategies in Bonjour (1998), Swinburne (2001), and Peacocke (2004) aiming to establish the a priority of certain ampliative modes of inference or abductive principles. (shrink)

In everyday causal explanations of human behaviour, known generally as folk psychology,' the causal powers of the mental seem to be taken for granted. Mental properties such as perceptions, beliefs, and desires, are all called upon in causal explanations of events that are deemed intentional. Jaegwon Kim's exclusion principle has led him to deny mental properties causal efficacy unless they are metaphysically reduced to physical properties, but what of their causal relevance? By giving up the assumption of causally efficacious mental (...) properties, has Kim put into question the explanatory value of explanations with mental descriptions? In other words, if a lower order neurological causal explanation involving a causally efficacious property is at hand, does it make the higher order mental explanation irrelevant and therefore redundant? If we are to save the explanatory importance of higher order predicates, and thus the causal explanations of the special sciences and folk psychology, we need an account of how such properties can be relevant as opposed to irrelevant in causal explanations, even though they may not be causally efficacious. Frank Jackson's and Philip Pettit's notion of program explanation tries to do just this. (shrink)

Within Ajzen's Planned Behavior Theory framework, this article tests a model to estimate the predictors of entrepreneurial intention in academic scientists working in Chile. We adapted into Spanish the entrepreneurship intention questionnaire. We tested the entrepreneurship intention model on a sample of 1,027 scientists leading research projects funded by the Chilean Scientific and Technological Development Fund, the country's primary scientific research grant. The results show strong empirical support for the entrepreneurship intention model proposed while highlighting some critical issues specific (...) to entrepreneurial intention in scientists. In particular, we found an indirect effect of perceived subjective social support on entrepreneurial intention, which is mediated by entrepreneurial attitude and perceived behavioral control toward entrepreneurship. These results suggest that policies orientated toward promoting academic entrepreneurship should include developing a healthy social environment toward it, meaning that entrepreneurial intention is not only an individual but an organizational challenge. These policies should analyze the social norms guiding the scientists' reference groups to increase their effectiveness. (shrink)

David Wallace has given a decision-theoretic argument for the Born Rule in the context of Everettian quantum mechanics. This approach promises to resolve some long-standing problems with probability in EQM, but it has faced plenty of resistance. One kind of objection charges that the requisite notion of decision-theoretic uncertainty is unavailable in the Everettian picture, so that the argument cannot gain any traction; another kind of objection grants the proof’s applicability and targets the premises. In this article I propose some (...) novel principles connecting the physics of EQM with the metaphysics of modality, and argue that in the resulting framework the incoherence problem does not arise. These principles also help to justify one of the most controversial premises of Wallace’s argument, ‘branching indifference’. Absent any a priori reason to align the metaphysics with the physics in some other way, the proposed principles can be adopted on grounds of theoretical utility. The upshot is that Everettians can, after all, make clear sense of objective probability. 1 Introduction2 Setup3 Individualism versus Collectivism4 The Ingredients of Indexicalism5 Indexicalism and Incoherence5.1 The trivialization problem5.2 The uncertainty problem6 Indexicalism and Branching Indifference6.1 Introducing branching indifference6.2 The pragmatic defence of branching indifference6.3 The non-existence defence of branching indifference6.4 The indexicalist defence of branching indifference7 Conclusion. (shrink)

Every paper in this collection is worth reading, for one reason or another. Still, due to certain problematic metametaphysical presuppositions most of these discussions miss the deeper mark, on the pessimist as well as the optimist side. My reasons for thinking this come from considering how best to answer three metametaphysical questions. First, why be pessimistic about metaphysics – why be Carnapian in a post-positivist age? There is, I’ll suggest, a post-positivist strategy for reviving Carnapian pessimism, but it is almost (...) entirely neglected here; and the motivations that pessimists offer instead are not compelling. Second, why think that the best way to approach metametaphysical questions is by attention to features of language, and in particular to quantifier semantics, in ordinary or ontological language(s)? Here again we are offered little motivation for this supposition, which, notwithstanding its acceptance by nearly all contributors, faces clear difficulties. Third, granting that quantification is somehow bound up with first-order questions about what exists, what is the nature of this connection, and what are the associated implications for metametaphysics? Here I find the accounts of the connection on offer implausible, especially as compared to an alternative that makes better sense of metaphysical practice and disagreement. The moral following consideration of these questions is that real progress in metametaphysics is likely to occur less by attention to semantic issues pertaining to representation, translation and quantification and more to non-semantic issues pertaining to epistemology and metaphysical determinacy. (shrink)

It is well known that Kant bases morality on the autonomy of the will, which he defines as the "the property of the will by which it is a law to itself" (GMS 4:440). He thus locates the normative basis for all the demands of morality in the capacity of persons to be self-legislating. Many philosophers take this to be an attractive and distinctively modern form of moral theory. It establishes the individual's own reason as the highest authority in the (...) moral realm and grants her the capacity to subject any and all norms to rational scrutiny. However, many of Kant's less sympathetic critics reject this picture of morality because they find the concept of individual autonomy incoherent. In particular, many do not think that self-imposed laws can be binding in any meaningful sense. Laws that one gives oneself cannot really be laws. For this reason, the very idea of self-legislation seems "absurd," as Elizabeth Anscombe so pointedly puts the matter. (shrink)

Popper’s view of scientific activity appears to take its social and communitarian features largely for granted. Rather than making this inter-subjectivity the basic problematic in his work, he wanted to move beyond language without, however, foreclosing the possibility that communication may often be a source of confusion in research and related scientific activity. Popper feared that the study of science, no less than scientific activity itself, may be led astray by an overly reflexive approach and focus. There are aspects of (...) his views on this matter which bear a considerable resemblance to Bacon, even though Popper is clearly a Cartesian deductivist rather than a Baconian inductivist, for reasons that become apparent in The Logic of Scientific Discovery. According to Popper, no such practice or method of discovery exists, either in science or anywhere else. (shrink)

Individual organisms are obvious enough kinds of things to have been taken for granted as the entities that have many commonly attributed biological and psychological properties, both in common sense and in science. The sorts of morphological properties used by the folk to categorize individual animals and plants into common sense kinds (that's a dog; that's a rose), as well as the properties that feature as parts of phenotypes, are properties of individual organisms. And psychological properties, such as believing that (...) taxes are too low, and remembering the last seven digits you read in the phone book, are likewise properties of individual organisms. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Hume on the Abstract Idea of Existence: Comments on Cummins' "Hume on the Idea of Existence"1 Fred Wilson Hume'sviews on theconceptofexistence: thisisone ofthemore obscure parts of Hume's philosophy. Professor Cummins has done a valuable service simply by trying to unravel some ofthe puzzles; it is still more valuable for shedding as much light as it does on the issues. There are nonetheless problems with the interpretation that he (...) develops, and I would like to bring out some ofthese. I will address three questions: (a)What, more precisely, is the (abstract) idea ofexistence? (b)What is the notion of"necessity" as Hume would use it in connection with the notion that something exists "necessarily," or, contrarily, "contingently"? (c)Does it follow from the fact that whatever thing we conceive we conceive as existent that every thing necessarily exists? In order toanswerthese questions somethingwillhave tobe said about Hume's doctrine ofabstractideas. Butonall theseissues, Humeis often not so much inadequate as incomplete; and I shall suggest that a numberofpoints canbeilluminatedbylookingatthe historical context that Hume himselfcould take for granted. The upshot will not be that Hume's views are unproblematic, but only that they are perhaps less problematic than Professor Cummins makes out. I. Abstract Ideas In many respects, Hume's doctrine of ideas is fairly traditional. We think in terms ofideas. In particular, our capacity to think generally, and to use general terms, is a matter ofhaving abstract ideas. In this, Hume follows the views ofhis predecessors such as Locke, Descartes and the Port Royal logicians. Hume also adopts the principle that what is conceivable is possible. Again, he follows the same tradition ofLocke, Volume XVII Number 2 167 FRED WILSON Descartes and the Port Royal logicians. Where Hume differs from his predecessors is in his account of what precisely an abstract is. For Hume's predecessors, one forms an abstract idea by separation. Thus, for Locke, forming ideas by abstraction consists in "separating them from all other Ideas that accompany them in their real existence."2 This sortofseparation is the mechanism bywhich "the Mind makes the particular Ideas, received from particular Objects, to become general" (Essay, 2.11.9). The Port Royal logicians make the same point: abstraction occurs with respect to "choses... composées" when one "les considérant par parties, et comme par les diverses faces qu'elles peuvent recevoir." In abstraction what is thus known is considered separately from the whole; either one considers "les parties séparément" in the case of"parties intégrantes," or one "peut séparer les choses en divers modes," or, finally, "quand une même chose ayant divers attributs, on pense à l'un sans penser à l'autre."3 The former occurs when, for example, we separate in thought the parts ofthe body. Thisis the simplestform ofabstraction. Berkeleyhas noproblems with this notion: "Iwill notdenyI can abstract, ifthatmay properlybe called abstraction, which extends only to the conceiving separately such objects, as is possible may really exist or be actually perceived asunder."4 Neither does Hume have problems with this notion; it is the basis of his—and Berkeley's—view that ideas are either simple or complex and that some of the complex ideas are a result of our combining simple parts in ways that are not found in reality, as, for example, in our idea ofthe New Jerusalem.5 It is the other two sorts ofabstraction that are more problematic. Consider the first of these two forms of abstraction. We begin with simple ideas ofsensation, for example, white (Essay, 2.3.1). One forms the abstract idea of white by separating the property white from the other qualities with which it is conjoined in the white particulars, for example, snow or milk (Essay, 2.21.73), that are given in sense experience. The resultingideais distinct from other ideas, for example, blue or heat (Essay, 2.12.1). The example given by Nicole and Arnauld is thatofthe geometers who explore the idea ofthree-dimensional space by considering first length alone, then area, and finally volumes or solids (which is the same, for these Cartesians as "corps," body) (Logique, 1.5). This is one form ofseparation. By this means one forms abstract... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:To Cut or Not to Cut?That is the QuestionTracy WilsonWhat is circumcision? In simple terms, it is the removal or excision of the foreskin of the penis. Seems so simple, right? In some families, it is that simple. In other families, it is a religious exercise. I am a doctorally-prepared Family Nurse Practitioner and started my nursing career in the NICU. I have seen my fair share of circumcisions. (...) As a nurse, our role was to prep the room with whichever instrument the OB/GYNS preferred and then soothe the baby. Some OB/GYNS prescribed Sucrose, which is ultimately sugar water, for the babies to have while undergoing circumcision, while others wouldn't prescribe anything. What I learned in the NICU and by watching circumcisions being performed was that the doctor's preference determined the pain management protocol. Some doctors cared more about pain control, some cared [End Page 85] about presentation and ensuring the foreskin was cut properly, and some were just old school and had their preferences. I wanted to comfort the baby and make his world as comfortable as possible.Watching circumcisions being performed, I never formed an opinion about them. I really looked at circumcision like any other procedure. However, I did see some parents really toil over the decisions, especially fathers who did not want to "see their son tortured or mutilated like that" as one told me once. I didn't quite understand the comparison to mutilation, but I understood why he did not want his son to go through the procedure. It wasn't until years later that I understood the gravity of the decision when I became pregnant with our son and knew immediately it was a boy. Call it a mother's intuition, but I just knew. To circumcise my son was never a decision I had to deliberate very long because it was something I was accustomed to in my family. It wasn't until one of my relatives got married and had her first son that I became aware that this would ever be a weighty decision for someone in my family.I took it for granted all those years before working in the NICU because circumcision was superficial to me. I realized that it's not just a piece of foreskin to many people. For some circumcision is done for religious reasons, for others making the choice to circumcise is about sameness, or hygiene. For my extended family member, it happened to be about sameness. She didn't want her sons to look different from their dad. Since potty training was mostly going to be taught by their father, they wanted their sons to look like him. Many NICU parents told me they wanted their sons to look like their fathers, so this notion was familiar to me. After my extended family member explained why sameness mattered, I understood the reasons why some parents felt this way.There are other stories like this which we pondered upon when we got pregnant with our son, and I really began to reflect on whether we should circumcise or not. Then two additional frames of thoughts arose; one, I ensured that my husband and I jointly made the decision together, but I really leaned on him for his opinion because he was a male and most of the male teaching would come from him. Second, we considered if the decision to circumcise should come from him once he became an adult. His father and I discussed whether he should have a choice regarding being circumcised. He may have chosen a different decision than us and we didn't want to take away his right to choose. However, waiting to have a circumcision as an adult comes with its own sets of challenges, including the possibility of infection, increased pain, missed work, edema, etc. So, ultimately, we made the decision to go ahead with the circumcision.In our case, our pediatrician performed the circumcision. I asked him explicitly which instrument he used because I had my preference, and I was not going to allow my son to be circumcised by a healthcare professional that did not use my... (shrink)

Charles Travis’s new collection on perception brings together eleven of his previously published essays on this topic, some of which are substantially revised, plus one new essay. The intentionally ambiguous subtitle hints at the author’s endorsement of Fregean anti-psychologism, though influences from Wittgenstein and Austin are equally apparent. The work centres around two major questions in the philosophy of mind and perception. First, Travis argues against the view that perceptual experience, as distinct from perceptual judgement or belief, is representational, and (...) so belongs to what Travis calls ‘the conceptual’. This is contrasted with the ‘non-conceptual’, or ‘historical’; that is, environmental particulars which lack the generality of representational thought. The second is what Travis calls ‘the fundamental question of perception’; namely, how can perceptual experience make the world bear (rationally) upon what we are to think and do? The answer, he argues, cannot be found in terms of relations between thoughts—a purely conceptual affair—but in the way that thought is itself grounded in the particularity of experience. For perceptual experience to bear rationally upon thought at all—or, in more familiar Fregean terms, to bring ‘objects’ under ‘concepts’—perception must first make environmental particulars available to cognition. Thus, Travis argues, experience cannot itself be ‘conceptual’, or representational, on pain of undermining the very thing that grants us a recognisable, and so thinkable, world at all. (shrink)

This paper focuses on the ethical justifiability of patents on Genetically Modified (GM) crops. I argue that there are three distinguishing features of GM crops that make it unethical to grant patents on GM crops, even if we assume that the patent system is in general justified. The first half of the paper critiques David Resnik’s recent arguments in favor of patents on GM crops. Resnik argues that we should take a consequentialist approach to the issue, and that the (...) best way to do so is to apply the Precautionary Principle, and that the Precautionary Principle, in this case, supports patents on GM crops. I argue that his argument in favor of a consequentialist treatment is invalid; his Precautionary Principle in any case appears to be incompatible with consequentialism; and his conception of reasonable precautions is too ill-defined to have any argumentative purchase. In the second half of the paper, I argue against GM crop patents, on three grounds. First, there is insufficient evidence to say whether allowing patents on GM crops will make research go faster than not having patents, whilst there is a good reason to think that, other things being equal, a society that allows patents on GM crops will be less just than one that does not. Second, even assuming that patents on GM crops will increase the pace of GM crop research, there is no social need to do so. Third, patents on GM crops will frequently have ethically unacceptable side effects. (shrink)

This is a book that challenges the current orthodoxy, both in the philosophy of mind and in the cognitive sciences, that thinking (construed broadly to include perceiving, imagining, remembering, etc.) is a mental process in the head. Such a view has been largely taken for granted since the demise of behaviorism in the 1960s, and it underpins both the representational and computational theories of mind, including their connectionist and dynamicist variants. While the orthodoxy has been rejected in recent years by (...) a motley collection of e-theorists—externalists, embodiers, embedders, and extended minders—Melser’s view is quite distinct from such views. For Melser, rather than thinking being a process that begins in the head but extends beyond it (as most e-theorists hold), it is a personal-level activity, something that a person does through her actions. Since Melser views such activities as being disjoint from natural processes, thinking is not a natural process at all, the sort of thing that we might study scientifically. Thus, thinking is a personal action that calls for a different kind of study, one that draws on empathy, interpretation, and hermeneutics. That is the view defended at the core of the book (chh.1-7), and if it makes it sound like a very old-fashioned book, that’s because it is. Melser’s antecedents are philosophers such as Gilbert Ryle, J.L. Austin, and Stuart Hampshire, both in style and in content. Apart from Melser’s heavy reliance on selective parts of developmental psychology, there is minimal discussion of substantive work in contemporary cognitive science. That is what might be expected from an author whose view is that whatever it is cognitive scientists are doing, it is not (much to their surprise, no doubt) the investigation of thinking. As I will try to show in a moment, however, the central argument of the book could have been strengthened by more direct engagement with such empirical work. (shrink)

Working memory limits are best defined in terms of the complexity of the relations that can be processed in parallel. Complexity is defined as the number of related dimensions or sources of variation. A unary relation has one argument and one source of variation; its argument can be instantiated in only one way at a time. A binary relation has two arguments, two sources of variation, and two instantiations, and so on. Dimensionality is related to the number of chunks, because (...) both attributes on dimensions and chunks are independent units of information of arbitrary size. Studies of working memory limits suggest that there is a soft limit corresponding to the parallel processing of one quaternary relation. More complex concepts are processed by or In segmentation, tasks are broken into components that do not exceed processing capacity and can be processed serially. In conceptual chunking, representations are to reduce their dimensionality and hence their processing load, but at the cost of making some relational information inaccessible. Neural net models of relational representations show that relations with more arguments have a higher computational cost that coincides with experimental findings on higher processing loads in humans. Relational complexity is related to processing load in reasoning and sentence comprehension and can distinguish between the capacities of higher species. The complexity of relations processed by children increases with age. Implications for neural net models and theories of cognition and cognitive development are discussed. (shrink)

Neuroscience has begun to elucidate the mechanisms of volition, decision-making, and action. Some have taken the progress neuroscience has made in these areas to indicate that we are not free to choose our actions . The notion that we can consciously initiate our behavior is a crucial tenet in the concept of free will, and closely linked to how most individuals view themselves as persons. There is thus reason to inquire if the aforementioned inference drawn by some might be too (...) hasty. While there is much evidence appearing to indicate that consciousness does not influence behavior—including evidence indicating that neural activity precedes a decision by several seconds, neural activity predicts what action an individual will perform, and that individuals infer when they decided to act after an action was performed—this evidence seems to suffer methodological issues. Additionally, there are empirically supported interpretations of the aforementioned data consistent with the idea that individuals can consciously control their actions. This paper therefore concludes that neuroscience does not currently substantiate the idea that we cannot consciously initiate or control our actions. (shrink)

The core issue of our target article concerns how relational complexity should be assessed. We propose that assessments must be based on actual cognitive processes used in performing each step of a task. Complexity comparisons are important for the orderly interpretation of research findings. The links between relational complexity theory and several other formulations, as well as its implications for neural functioning, connectionist models, the roles of knowledge, and individual and developmental differences, are considered.

In lieu of an abstract, here is a brief excerpt of the content:460 HISTORY OF PHILOSOPHY accurate understanding of the mind of Aristotle. Nifo's shift on the question of Aristotle and immortality thus represents a noteworthy chapter in the history of Renaissance Aristotelianism.6x EDWAKDP. MAHONEY Duke University 6x I should like to thank the United States Government for a Fulbright fellowship during 1962-1963; the National Foundation for the Humanities for a fellowship during 1968-1969; and the Duke UniversityResearch Council for grants (...) for microfilms. BIBLIOGRAPHY OF THE WRITINGS OF JACOB LOEWENBERG Compiled by Edwin S. Budge It is hoped that all of Professor Loewenberg's published writings, exclusive of his many book reviews, are listed herein. His unpublished doctoral dissertation, "The Genesis of Hegel's Dialectical Method" (1911), is available on loan from Harvard University, although the "gist" of this, as Dr. Loewenberg has indicated, may be found in the introduction to the first item cited in the bibliography. Dr. Loewenberg, it might be added, also translated a short work by Gilbert Chinard, France for the Soldier (Berkeley: University of California, 1918), and quite likely was consulted by his wife Kate in the course of her translation of Emile Meyerson's Identity and Reality (New York: Macmillan Company, 1930; reprinted by Dover, 1962, and Peter Smith, 1963). Jacob Loewenberg's personal papers are in the possession of his daughter, Mrs. Jeannot Nyles, of Berkeley, California. 1912 1916 BIBLIOGRAPHYOF THE WRITINGSOF JACOBLOEWENBERG "Vorwort," pp. v-vi; "Einleitung: 'Die jugendlichen Denkversuche Hegels'," pp. vii-xxii; in Hegels Entwiir/e zur Enzyklopiidie und Propiideutik nach den Handschri/ten der Harvard-Universitiit. Mit einer Handschri[tprobe. By Georg Wilhelm Friedrich Hegel. Herausgegeben yon Dr. J. Ltwenberg. Leipzig: Verlag von Felix Meiner, I912. xxiv, 59 pp. (Hegel-Archiv. Herausgegeben von Georg Lasson. Band I, Heft 1.) "Interpretation as a Self-Representative Process," The Philosophical Review, Vol. XXV, No. 3 (May, 1916), 420-423. "Mysticism and Idealism," University o/ California Chronicle, Vol. XVIII, No. 1 (January, 1916), 72-91. "An address before the Philosophical Union of the University of California, December 10, 1915." 1917 1918 1919 1920 1921 1922 1923 NOTES AND DISCUSSIONS 461 "The Spirit of Hegel's Philosophy," University of California Chronicle, Vol. XVIII, No. 3 (July, 1916), 373-393. "The Teachings of Royce," The California Alumni Fortnightly, Vol. IX, No. 14 (September 30, 1916), 216-217. "Classic and Romantic Trends in Plato," The Harvard Theological Review, Vol. X, No. 3 (July, 1917), 215-236. "An address before the Philosophical Union of the University of California, February 23, 1917." "Josiah Royce: Interpreter of American Problems," University of California Chronicle, Vol. XIX, No. 1 (January, 1917), 39-47. "The Prophetic Songs of Swinburne," University of California Chronicle, Vol. XX, No. 10anuary, 1918), 106-115. "Preface," pp. vii-xii in Lectures on Modern Idealism. By Josiah Royce. New Haven: Yale University Press, 1919. Pp. 259. (Semicentennial Publications of the University of California, 1868-1918.) "Ethics and the War," Mills Quarterly, Vol. I, No. 4 0anuary, 1919), 6-9. "An address delivered at Mills College, October 18, 1918." "Multiplicity and the Social Order," The Harvard Theological Review, Vol. XII, No. 2 (April, 1919), 137-164. "President Wilson's Americanism," University of California Chronicle, Vol. XXI, No. 1 (January, 1919), 1-15. "Introduction," pp. 3-37 in Fugitive Essays; with an Introduction by Dr. J. Loewenberg. By Josiah Royce. Cambridge: Harvard University Press, 1920. Pp. 429. (Semicentennial Publications of the University of California, 1868-1918.) "Philosophy and Humanism," University of California Chronicle, Vol. XXIH, No. 3 (July, 1921), 298-318. "Read before the Kosmos Club of the University of California, April 4, 1921." "The Apotheosis of Mind in Modern Idealism," The Philosophical Reviewj Vol. XXXI, No. 3 (May, 1922), 215-236. "A fragment of a larger essay." "The Idea of Mutability in Literature," University of California Chronicle, Vol. XXIV, No. 2 (April, 1922), 129-151. "The Metaphysics of Critical Realism," pp. 167-194 in Issues and Tendencies in Contemporary Philosophy. Edited by George P. Adams and J. Loewenberg. 462 HISTORY OF PHILOSOPHY Berkeley: University of California, 1923, Pp. 224. (University of California Publieations in Philosophy, VoL IV.) Read before the Philosophical Union of the University of California, March 30, 1923. "'The Metaphysics of Modern Scepticism," The Philosophical... (shrink)

Experts identified water quality, manure, good handling practices (including personal hygiene and equipment sanitation), and traceability as critical farm problem areas that, if addressed, are likely to decrease risk associated with microbial contamination of fresh produce from all scales of agriculture. However, the diverse nature of production strategies used by produce farmers presents multiple options for addressing foodborne illness issues while simultaneously creating potential complications. We use a mental models methodology to enhance our understanding of the underlying factors and assumptions (...) of small, medium, and large produce growers that influence their decision-making processes for contamination prevention and control. This empirical evidence demonstrates how challenges and opportunities to food safety are related to the scale of production and marketing strategies. We believe that refining the development of standards and existing extension and outreach food safety programs are important to both consumer protection and supporting agricultural communities. Additionally, this approach will help develop and refine food safety programs that will result in empirically grounded recommendations based on identified grower information needs. (shrink)

This study focused on the state-level implementation of the Common Core English Language Arts (CC-ELA) standards and the implications for state education department personnel in social studies. Researchers employed a mixed methods approach to data collection and analysis asking the following research questions: (1) How do state-level social studies coordinators understand the obligations and implications of the CC-ELA standards for social studies? and (2) What benefits and challenges do they anticipate the CC-ELA standards offer to social studies educators? Findings from (...) the survey and interviews offer a glimpse into the thinking of social studies coordinators. The findings clustered around four assertions: (1) Coordinators were generally supportive of the CC-ELA standards, (2) CC-ELA is changing the way social studies is enacted at the state level, (3) Coordinators were cautiously optimistic about the impact of CC-ELA on elementary social studies, and (4) Coordinators were consistently positive about the impact of CC-ELA on secondary social studies. The positive views of the CC-ELA standards, however, appeared to do little to mitigate the challenge that the state coordinators face as they translate the standards and teach them to social studies teachers across their states. (shrink)

Working parents in are struggling to balance the demands of their occupation with those of childcare and homeschooling during the COVID-19 pandemic. Moreover, studies show that women are shouldering more of the burden and reporting greater levels of psychological distress, anxiety, and depression relative to men. However, research has yet to show that increases in psychological symptoms are linked to changes in stress during the pandemic. Herein, we conduct a small-N study to explore the associations between stress and psychological symptoms (...) during the pandemic among mothers using structural equation modeling, namely latent change score models. Thirty-three mothers completed questionnaires reporting current anxious and depressive symptoms, as well as stressful life experiences prior to-versus during the pandemic. Women endorsed significantly more stressful events during the pandemic, relative to the pre-pandemic period. Additionally, 58% of mothers scored as moderate-to-high risk for developing a stress-related physical illness in the near future because of their pandemic-level stress. Depressive symptoms were associated with the degree of change in life stress, whereas anxiety symptoms were more related to pre-pandemic levels of stress. The present study preliminarily sheds light on the nuanced antecedents to mothers’ experiences of anxious and depressive symptoms during the COVID-19 pandemic. Although further work is needed in larger, more diverse samples of mothers, this study highlights the potential need for appropriate policies, and prevention and intervention programs to ameliorate the effects of pandemics on mothers’ mental health. (shrink)

This article is guided by principles and practices of bioethics and public health ethics focused on health care reform within the context of promoting Optimal Health. The Tuskegee University National Center for Bioethics in Research and Health Care is moving beyond the traditions of bioethics to incorporate public health ethics and Optimal Health. It is imperative to remember the legacy of the ill-fated research entitled Tuskegee Study of Untreated Syphilis in the Negro Male. Human participant research and health care must (...) be connected to principles of bioethics and public health ethics if the Affordable Care Act is expected to positively impact on the health of people living in the United States. Optimal Health describes a strategy to achieve individual and population health. Health care reform offers an opportunity to shift from the traditional pathology focus of managing diseases to target disease prevention and health promotion with a new set of tools. Transformational change is possible if the lessons learned from the U.S. Public Health Service Syphilis Study at Tuskegee are considered and strategies in bioethics and public heath ethics are employed. (shrink)

In the latter half of the twentieth century, philosophers of science have argued (implicitly and explicitly) that epistemically rational individuals might compose epistemically irrational groups and that, conversely, epistemically rational groups might be composed of epistemically irrational individuals. We call the conjunction of these two claims the Independence Thesis, as they together imply that methodological prescriptions for scientific communities and those for individual scientists might be logically independent of one another. We develop a formal model of scientific inquiry, define four (...) criteria for individual and group epistemic rationality, and then prove that the four definitions diverge, in the sense that individuals will be judged rational when groups are not and vice versa. We conclude by explaining implications of the inconsistency thesis for (i) descriptive history and sociology of science and (ii) normative prescriptions for scientific communities. (shrink)

Modeling and computer simulations, we claim, should be considered core philosophical methods. More precisely, we will defend two theses. First, philosophers should use simulations for many of the same reasons we currently use thought experiments. In fact, simulations are superior to thought experiments in achieving some philosophical goals. Second, devising and coding computational models instill good philosophical habits of mind. Throughout the paper, we respond to the often implicit objection that computer modeling is “not philosophical.”.

© Copyright 2015, Mary Ann Liebert, Inc..Signal transducer and activator of transcription factor 3 is hyperactivated in head and neck squamous cell carcinomas. Cumulative evidence indicates that IL-6 production by HNSCC cells and/or stromal cells in the tumor microenvironment activates STAT3 and contributes to tumor progression and drug resistance. A library of 94,491 compounds from the Molecular Library Screening Center Network was screened for the ability to inhibit interleukin-6 -induced pSTAT3 activation. For contractual reasons, the primary high-content screening campaign was (...) conducted over several months in 3 distinct phases; 1,068 primary HCS actives remained after cytotoxic or fluorescent outliers were eliminated. One thousand one hundred eighty-seven compounds were cherry-picked for confirmation; actives identified in the primary HCS and compounds selected by a structural similarity search of the remaining MLSCN library using hits identified in phases I and II of the screen. Actives were confirmed in pSTAT3 IC50 assays, and an IFNγ-induced pSTAT1 activation assay was used to prioritize selective inhibitors of STAT3 activation that would not inhibit STAT1 tumor suppressor functions. Two hundred three concentration-dependent inhibitors of IL-6-induced pSTAT3 activation were identified and 89 of these also produced IC50s against IFN-γ-induced pSTAT1 activation. Forty-nine compounds met our hit criteria: they reproducibly inhibited IL-6-induced pSTAT3 activation by ≥70% at 20 μM; their pSTAT3 activation IC50s were ≤25 μM; they were ≥2-fold selective for pSTAT3 inhibition over pSTAT1 inhibition; a cross target query of PubChem indicated that they were not biologically promiscuous; and they were ≥90% pure. Twenty-six chemically tractable hits that passed filters for nuisance compounds and had acceptable drug-like and ADME-Tox properties by computational evaluation were purchased for characterization. The hit structures were distributed among 5 clusters and 8 singletons. Twenty-four compounds inhibited IL-6-induced pSTAT3 activation with IC50s ≤20 μM and 13 were ≥3-fold selective versus inhibition of pSTAT1 activation. Eighteen hits inhibited the growth of HNSCC cell lines with average IC50s ≤ 20 μM. Four chemical series were progressed into lead optimization: the guanidinoquinazolines, the triazolothiadiazines, the amino alcohols, and an oxazole-piperazine singleton. (shrink)

Healthcare workers are often assumed to have a duty to work, even if faced with personal risk. This is particularly so for professionals. However, the health service also depends on non-professionals, such as porters, cooks and cleaners. The duty to work is currently under scrutiny because of the ongoing challenge of responding to pandemic influenza, where an effective response depends on most uninfected HCWs continuing to work, despite personal risk. This paper reports findings of a survey of HCWs conducted across (...) three National Health Service trusts in the West Midlands, UK, to establish whether HCWs’ likelihood of working during a pandemic is associated with views about the duty to work. The sense that HCWs felt that they had a duty to work despite personal risk emerged strongly regardless of professional status. Besides a strong sense that everyone should pull together, all kinds of HCWs recognised a duty to work even in difficult circumstances, which correlated strongly with their stated likelihood of working. This suggests that HCWs’ decisions about whether or not they are prepared to work during a pandemic are closely linked to their sense of duty. However, respondents’ sense of the duty to work may conflict with their sense of duty to family, as well as other factors such as a perceived lack of reciprocity from their employers. Interestingly, nearly 25% of doctors did not consider that they had a duty to work where doing so would pose risks to themselves or their families. (shrink)

P S Wilson; Interests, Values and Educational Language, Journal of Philosophy of Education, Volume 10, Issue 1, 30 May 2006, Pages 147–166, https://doi.org/10.1.

The sequencing of the human genome and decreasing costs of sequencing technology have led to the notion of ‘personalized medicine’. This has been taken by some authors to indicate that personalized medicine will provide individualized treatments solely based on one’s DNA sequence. We argue this is overly optimistic and misconstrues the notion of personalization. Such interpretations fail to account for economic, policy and structural constraints on the delivery of healthcare. Furthermore, notions of individualization based on genomic data potentially take us (...) down the road of genetic reductionism obscuring the role of environmental factors in disease and ill health. We propose that one should see personalized medicine as a way of using personal genomic information to stratify individuals into subpopulations and suggest that personalized medicine be seen within a broader idea of personalized healthcare, reflecting healthcare that integrates personal genomic data into cultural, environmental and personal contexts. (shrink)